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Test ID PTP Porphyrins, Total, Plasma

Useful For

Monitoring treatment of patients with porphyria cutanea tarda

Genetics Test Information

Plasma specimens from patients with active porphyria cutanea tarda, congenital erythropoietic porphyria, and erythropoietic protoporphyria may exhibit increased plasma porphyrin levels. However, a definitive diagnosis cannot be made by plasma analysis alone.

Highlights

Plasma porphyrins are most appropriate for monitoring patients being treated for porphyria cutanea tarda.

 

Analysis of plasma porphyrins is suitable for individuals with bullous dermatosis who are in kidney failure and unable to provide a urine specimen.

Method Name

PTP: Extraction and Scanning Spectrofluorometry

PFP: High-Performance Liquid Chromatography (HPLC)

Reporting Name

Porphyrins, Total, P

Specimen Type

Plasma


Shipping Instructions


Ship specimen in amber vial to protect from light.



Necessary Information


Include a list of medications the patient is currently taking.



Specimen Required


Patient Preparation: Patient must not consume any alcohol for 24 hours before specimen collection.

Supplies: Amber Frosted Tube, 5 mL (T915)

Collection Container/Tube:

Preferred: Green top (sodium or lithium heparin)

Acceptable: Lavender top (EDTA)

Submission Container/Tube: Amber vial

Specimen Volume: 3 mL

Collection Instructions:

1. Centrifuge specimen and aliquot plasma into amber vial.

2. Send plasma frozen.


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Frozen 14 days LIGHT PROTECTED

Reference Values

≤1.0 mcg/dL

Day(s) Performed

Monday through Friday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

84311-Porphyrins, total

82542-Porphyrins, fractionation (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PTP Porphyrins, Total, P 2815-9

 

Result ID Test Result Name Result LOINC Value
8731 Porphyrins, Total, P 2815-9
34252 Reviewed By 18771-6
33869 Interpretation 59462-2

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
PFP Porphyrins, Fractionation, P No No

Testing Algorithm

If total porphyrins are above 1.0 mcg/dL, then porphyrin fractionation will be performed at an additional charge.

 

The following algorithms are available:

-Porphyria (Acute) Testing Algorithm

-Porphyria (Cutaneous) Testing Algorithm

Report Available

2 to 4 days

NY State Approved

Yes