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Test ID NMHR1 N-Methylhistamine, Random, Urine


Ordering Guidance


Patients with chronic mast cell activation often have chronically elevated N-methylhistamine (NMH) levels and will sometimes have intermittent NMH elevations. In these cases, a 24-hour urine collection is preferred. See NMH24 / N-Methylhistamine, 24 Hour, Urine.



Specimen Required


Only orderable as part of a profile. For more information see NMHR / N-Methylhistamine, Random, Urine.

 

Patient Preparation: Patient must not be taking monoamine oxidase inhibitors (MAOI) or aminoguanidine as these medications increase N-methylhistamine (NMH) levels.

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Container/Tube: Plastic, 5-mL tube

Specimen Volume: 5 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.


Useful For

Screening for and monitoring of mastocytosis and disorders of systemic mast-cell activation, such as anaphylaxis and other forms of severe systemic allergic reactions as a part of a random urine collection profile

 

Monitoring therapeutic progress in conditions that are associated with secondary, localized, low-grade persistent, mast-cell proliferation and activation such as interstitial cystitis

Method Name

Only orderable as part of a profile. For more information see NMHR / N-Methylhistamine, Random, Urine.

 

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

N-Methylhistamine, Random

Specimen Type

Urine

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reference Values

Only orderable as part of a profile. For more information see NMHR / N-Methylhistamine, Random, Urine.

 

0-5 years: 120-510 mcg/g creatinine

6-16 years: 70-330 mcg/g creatinine

>16 years: 30-200 mcg/g creatinine

Day(s) Performed

Monday, Wednesday, Friday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82542

LOINC Code Information

Test ID Test Order Name Order LOINC Value
NMHR1 N-Methylhistamine, Random 13781-0

 

Result ID Test Result Name Result LOINC Value
605015 N-Methylhistamine, Random, U 13781-0

NY State Approved

Yes

Report Available

3 to 7 days

Specimen Minimum Volume

3 mL