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Test ID MUXF3 MUXF3 (Cross-reactive Carbohydrate Determinant), IgE, Serum


Ordering Guidance


For a listing of allergens available for testing, see Allergens - Immunoglobulin E (IgE) Antibodies



Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL for every 5 allergens requested

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Forms

If not ordering electronically, complete, print, and send an Allergen Test Request (T236) with the specimen.

Useful For

Evaluation for the presence of antibodies to cross-reactive carbohydrate determinates (CCD)

 

Investigation of clinically unexpected positive IgE antibody testing in a wide variety of plant and invertebrate allergens

Highlights

The presence of IgE antibodies to cross-reactive carbohydrate determinants (CCD), such as bromelain derived MUX3, are associated with broad cross-reactivity with many plant and invertebrate allergens (including peanut allergens).

 

The presence of antibodies to CCD are generally not associated with allergenic symptoms but can cause confounding positive specific IgE antibody tests to a broad variety of allergens.

Method Name

Fluorescence Enzyme Immunoassay (FEIA)

Reporting Name

MUXF3 (CCD), IgE, S

Specimen Type

Serum

Specimen Minimum Volume

For 1 allergen: 0.3 mL
For more than 1 allergen: (0.05 mL x number of allergens) + 0.25 mL deadspace

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  90 days
  Ambient  7 days

Reference Values

Class

IgE kU/L

Interpretation

0

<0.10

Negative

0/1

0.10-0.34

Borderline/equivocal

1

0.35-0.69

Equivocal

2

0.70-3.49

Positive

3

3.50-17.4

Positive

4

17.5-49.9

Strongly positive

5

50.0-99.9

Strongly positive

6

≥100

Strongly positive

 

Concentrations of 0.70 kU/L or more (class 2 and above) will flag as abnormally high.

 

Reference values apply to all ages.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86008

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MUXF3 MUXF3 (CCD), IgE, S 58984-6

 

Result ID Test Result Name Result LOINC Value
MUXF3 MUXF3 (CCD), IgE, S 58984-6

NY State Approved

Yes

Day(s) Performed

Monday through Friday

Report Available

Same day/1 to 3 days