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HelpTest ID MP9W Mucopolysaccharidoses, Nine-Enzyme Panel, Leukocytes
Ordering Guidance
To evaluate newborn patients in follow-up to an abnormal newborn screen for MPS II, the recommended tests are I2SB / Iduronate-2-Sulfatase, Blood Spot or I2SWB / Iduronate-2-Sulfatase, Leukocytes and MPSBS / Mucopolysaccharidosis, Blood Spot, MPSWB / Mucopolysaccharidosis, Blood, MPSER / Mucopolysaccharides Quantitative, Serum or MPSQU / Mucopolysaccharides Quantitative, Random, Urine.
Shipping Instructions
For optimal isolation of leukocytes, it is recommended the specimen arrive refrigerated within 6 days of collection to be stabilized. Collect specimen Monday through Thursday only and not the day before a holiday. Specimen should be collected and packaged as close to shipping time as possible.
Necessary Information
1. Patient's age is required.
2. Reason for testing is required.
Specimen Required
Container/Tube:
Preferred: Yellow top (ACD solution B)
Acceptable: Yellow top (ACD solution A) or lavender top (EDTA)
Specimen Volume: 6 mL
Collection Instructions: Send whole blood specimen in original tube. Do not aliquot.
Forms
1. New York Clients-Informed consent is required. Document on the request form or electronic order that a copy is on file. The following documents are available:
-Informed Consent for Genetic Testing (T576)
-Informed Consent for Genetic Testing-Spanish (T826)
2. If not ordering electronically, complete, print, and send a Biochemical Genetics Test Request (T798) with the specimen.
Useful For
Supporting the biochemical diagnosis of mucopolysaccharidoses types II, IIIA, IIIB, IIIC, IIID, IVA, IVB, VI, and VII, and of multiple sulfatase deficiency
This test is not useful for carrier detection.
Special Instructions
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
MPS (Nine) Panel, WBCSpecimen Type
Whole Blood ACDSpecimen Minimum Volume
5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole Blood ACD | Refrigerated (preferred) | 6 days | |
| Ambient | 6 days |
Reference Values
Iduronate-2-sulfatase: >2.20 nmol/hour/mg protein
Heparan-N-sulfatase: >0.13 nmol/hour/mg protein
N-acetyl-alpha-D-glucosaminidase: >0.09 nmol/hour/mg protein
Heparan-alpha-glucosaminide N-acetyltransferase: >0.24 nmol/hou/mg protein
N-acetylglucosamine-6-sulfatase: >0.03 nmol/hour/mg protein
N-acetylgalactosamine-6-sulfatase: >1.60 nmol/hour/mg protein
Beta-galactosidase: >0.28 nmol/hour/mg protein
Arylsulfatase B: >0.34 nmol/hour/mg protein
Beta-glucuronidase: >3.50 nmol/hour/mg protein
An interpretive report will be provided.
Day(s) Performed
Preanalytical processing: Monday through Saturday
Testing performed: Tuesday
Report Available
8 to 15 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82657
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| MP9W | MPS (Nine) Panel, WBC | 104072-4 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| BG759 | Reason for Referral | 42349-1 |
| 618439 | Iduronate-2-sulfatase | 24089-5 |
| 618440 | Heparan-N-sulfatase | 24086-1 |
| 618441 | N-acetyl-alpha-D-glucosaminidase | 24092-9 |
| 618442 | Heparan-alpha-glucosaminide N-acetyltransferase | 24044-0 |
| 618443 | N-acetylglucosamine-6-sulfatase | 24098-6 |
| 618444 | N-acetylgalactosamine-6-sulfatase | 24096-0 |
| 618445 | Beta-galactosidase | 24061-4 |
| 618446 | Arylsulfatase B | 24094-5 |
| 618447 | Beta-glucuronidase | 24065-5 |
| 618448 | Interpretation | 59462-2 |
| 618438 | Reviewed By | 18771-6 |