Sign in →

Test ID LAD1 Leukocyte Adhesion Deficiency Type 1, CD11a/CD18 and CD11b/CD18 Complex Immunophenotyping, Blood

Useful For

Aiding in the diagnosis of leukocyte adhesion deficiency syndrome type 1, primarily in patients younger than 18 years

 

CD11a, CD11b, and CD18 phenotyping

Genetics Test Information

ITGB2 is located on the long arm of chromosome 21(21q22.3). It encodes the common beta 2 integrin subunit (CD18), which is necessary for the expression of lymphocyte function-associated antigen 1 (CD11a/CD18), Mac-1/CR3 (CD11b/CD18), and p150/95 (CD11c/CD18).

 

Variants in this gene are the underlying cause for the autosomal recessive leukocyte adhesion deficiency type 1.

Method Name

Flow Cytometric Immunophenotyping

Reporting Name

Leukocyte Adhesion Def. Type 1, B

Specimen Type

Whole Blood EDTA


Shipping Instructions


Testing is performed Monday through Friday. Specimens not received by 4 p.m. (CST) on Friday may be canceled.

 

Draw and package specimen as close to shipping time as possible. It is recommended that specimens arrive within 24 hours of draw.

 

Specimens arriving on the weekend and observed holidays may be canceled.



Necessary Information


Date and time of collection and healthcare professional name and phone number are required.



Specimen Required


Container/Tube: Lavender top (EDTA)

Specimen Volume: 5 mL

Collection Instructions: Send whole blood specimen in original tube. Do not aliquot.

Additional Information: For serial monitoring, it is recommended that specimens are collected at the same time of day.


Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole Blood EDTA Ambient 72 hours PURPLE OR PINK TOP/EDTA

Reference Values

Normal (reported as normal or absent expression for each marker)

Day(s) Performed

Monday through Friday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

86356 x 3

LOINC Code Information

Test ID Test Order Name Order LOINC Value
LAD1 Leukocyte Adhesion Def. Type 1, B 94266-4

 

Result ID Test Result Name Result LOINC Value
81155 Leukocyte Adhesion Deficiency, B No LOINC Needed
430 CD11a 94268-0
388 CD11b 94267-2
431 CD18 94265-6
432 LAD Interpretation 69052-9

Test Classification

This test was developed using an analyte specific reagent. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

Report Available

3 to 4 days

NY State Approved

Yes