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HelpTest ID HYOX Hyperoxaluria Panel, Random, Urine
Useful For
Distinguishing between primary and secondary hyperoxaluria
Distinguishing between primary hyperoxaluria types 1, 2, and 3
Genetics Test Information
Primary hyperoxalurias, classified into types 1, 2, and 3, are genetic disorders of oxalate metabolism characterized by increased urinary excretion of oxalic acid and kidney stone formation.
Secondary hyperoxaluria is an acquired condition resulting from either increased intake of dietary oxalate or altered intestinal oxalate absorption.
Highlights
A diagnostic workup in an individual with hyperoxaluria demonstrates increased concentration of oxalate in urinary metabolite screening. If glycolate, glycerate, or 4-hydroxy-2-oxoglutarate is present, a primary hyperoxaluria is indicated.
Each type of primary hyperoxaluria is distinguished from the others based on the urine profile.
Special Instructions
Method Name
Gas Chromatography Mass Spectrometry (GC-MS)
Reporting Name
Hyperoxaluria Panel, USpecimen Type
UrineNecessary Information
1. Patient age is required.
2. Biochemical Genetics Patient Information (T602) is recommended, but not required, to be filled out and sent with the specimen to aid in the interpretation of test results.
Specimen Required
Supplies: Urine Tubes, 10 mL (T068)
Container/Tube: Plastic, 10-mL urine tube
Specimen Volume: 10 mL
Collection Instructions:
1. Collect a random urine specimen.
2. No preservative.
3. Immediately freeze specimen.
Specimen Minimum Volume
1.1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Frozen (preferred) | 90 days | |
| Refrigerated | 14 days |
Reference Values
GLYCOLATE
≤17 years: ≤75 mg/g creatinine
≥18 years: ≤50 mg/g creatinine
GLYCERATE
≤31 days: ≤75 mg/g creatinine
32 days - 4 years: ≤125 mg/g creatinine
5 - 10 years: ≤55 mg/g creatinine
≥11 years: ≤25 mg/g creatinine
OXALATE
≤6 months: ≤400 mg/g creatinine
7 months - 1 year: ≤300 mg/g creatinine
2 - 6 years: ≤150 mg/g creatinine
7 - 10 years: ≤100 mg/g creatinine
≥11 years: ≤75 mg/g creatinine
4-HYDROXY-2-OXOGLUTARATE (HOG)
≤10 mg/g creatinine
Day(s) Performed
Wednesday
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
82542
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| HYOX | Hyperoxaluria Panel, U | 53710-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 50592 | Glycolate | 13751-3 |
| 50593 | Glycerate | 13749-7 |
| 50594 | Oxalate | 13483-3 |
| 38049 | 4-hydroxy-2-oxoglutarate | 13678-8 |
| 29982 | Interpretation | 59462-2 |
| 29984 | Reviewed By | 18771-6 |
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.Testing Algorithm
For more information see Hyperoxaluria Diagnostic Algorithm.
Disease States
- Hyperoxaluria
Report Available
3 to 9 daysNY State Approved
YesForms
1. Biochemical Genetics Patient Information (T602)
2. If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-Biochemical Genetics Test Request (T798)
-Renal Diagnostics Test Request (T830)