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HelpTest ID HCYSS Homocysteine, Total, Serum
Useful For
An aid for screening patients suspected of having an inherited disorder of methionine metabolism including:
-Cystathionine beta-synthase deficiency (homocystinuria)
-Methylenetetrahydrofolate reductase deficiency and its thermolabile variants:
-Methionine synthase deficiency
-Cobalamin (Cbl) metabolism
-Combined methyl-Cbl and adenosyl-Cbl deficiencies: Cbl C2, Cbl D2, and Cbl F3 deficiencies
-Methyl-Cbl specific deficiencies: Cbl D-Var1, Cbl E, and Cbl G deficiencies
-Transcobalamin II deficiency
-Adenosylhomocysteinase deficiency
-Glycine N-methyltransferase deficiency
-Methionine adenosyltransferase I/III deficiency
Screening and monitoring patients suspected of, or confirmed with, an inherited disorder of methionine metabolism
Evaluating individuals with suspected deficiency of vitamin B12 or folate
Special Instructions
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Homocysteine, Total, SSpecimen Type
SerumNecessary Information
Patient's age and sex are required.
Specimen Required
Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial within 4 hours of collection.
Specimen Minimum Volume
0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Frozen | 309 days | ||
| Ambient | 28 days |
Reference Values
|
Age |
Total Homocysteine (nmol/mL) |
|
|
Female |
Male |
|
|
0-11 months |
3.1-8.3 |
3.2-9.7 |
|
12-23 months |
3.2-8.3 |
3.3-9.6 |
|
24-35 months |
3.2-8.2 |
3.3-9.6 |
|
3 years |
3.2-8.2 |
3.3-9.6 |
|
4 years |
3.3-8.2 |
3.4-9.5 |
|
5 years |
3.4-8.1 |
3.5-9.4 |
|
6 years |
3.5-8.1 |
3.6-9.4 |
|
7 years |
3.5-8.1 |
3.7-9.4 |
|
8 years |
3.6-8.2 |
3.8-9.3 |
|
9 years |
3.7-8.2 |
3.9-9.4 |
|
10 years |
3.8-8.3 |
4.1-9.4 |
|
11 years |
3.9-8.4 |
4.3-9.4 |
|
12 years |
3.9-8.6 |
4.4-9.5 |
|
13 years |
4.0-8.7 |
4.6-9.6 |
|
14 years |
4.1-8.8 |
4.8-9.7 |
|
15 years |
4.2-8.9 |
5.0-9.8 |
|
16 years |
4.2-9.1 |
5.2-9.9 |
|
17 years |
4.3-9.2 |
5.4-10.0 |
|
18 years |
4.3-9.3 |
5.6-10.1 |
|
19 years |
4.4-9.5 |
5.7-10.3 |
|
20 years |
4.4-9.6 |
5.9-10.5 |
|
21 years |
4.4-9.8 |
6.0-10.6 |
|
22 years |
4.4-9.9 |
6.1-10.8 |
|
23 years |
4.4-10.1 |
6.2-11.0 |
|
24 years |
4.4-10.3 |
6.2-11.1 |
|
25 years |
4.4-10.4 |
6.3-11.3 |
|
26 years |
4.4-10.6 |
6.3-11.4 |
|
27 years |
4.3-10.8 |
6.4-11.6 |
|
28 years |
4.3-11.0 |
6.4-11.7 |
|
29 years |
4.3-11.2 |
6.4-11.8 |
|
30 years |
4.3-11.4 |
6.4-11.9 |
|
31 years |
4.4-11.6 |
6.4-12.1 |
|
32 years |
4.4-11.8 |
6.4-12.2 |
|
33 years |
4.4-11.9 |
6.4-12.3 |
|
34 years |
4.5-12.1 |
6.4-12.4 |
|
35 years |
4.5-12.2 |
6.4-12.6 |
|
36 years |
4.6-12.4 |
6.4-12.8 |
|
37 years |
4.6-12.5 |
6.4-12.9 |
|
38 years |
4.7-12.7 |
6.4-13.1 |
|
39 years |
4.7-12.8 |
6.4-13.2 |
|
40 years |
4.8-13.0 |
6.5-13.4 |
|
41 years |
4.8-13.2 |
6.5-13.5 |
|
42 years |
4.8-13.4 |
6.5-13.7 |
|
43 years |
4.9-13.5 |
6.6-13.9 |
|
44 years |
4.9-13.7 |
6.6-14.0 |
|
45 years |
4.9-13.9 |
6.6-14.2 |
|
46 years |
4.9-14.0 |
6.7-14.4 |
|
47 years |
4.9-14.2 |
6.7-14.5 |
|
48 years |
5.0-14.3 |
6.8-14.7 |
|
49 years |
5.0-14.4 |
6.8-14.9 |
|
50 years |
5.0-14.5 |
6.8-15.0 |
|
51 years |
5.1-14.6 |
6.8-15.2 |
|
52 years |
5.1-14.7 |
6.9-15.4 |
|
53 years |
5.1-14.8 |
6.9-15.5 |
|
54 years |
5.2-14.9 |
6.9-15.6 |
|
55 years |
5.2-15.0 |
6.9-15.7 |
|
56 years |
5.3-15.0 |
6.9-15.8 |
|
57 years |
5.3-15.1 |
6.9-15.9 |
|
58 years |
5.3-15.2 |
6.9-16.0 |
|
59 years |
5.4-15.2 |
6.9-16.0 |
|
60 years |
5.4-15.3 |
6.9-16.1 |
|
61 years |
5.4-15.4 |
7.0-16.2 |
|
62 years |
5.5-15.4 |
7.0-16.2 |
|
63 years |
5.5-15.5 |
7.0-16.3 |
|
64 years |
5.6-15.5 |
7.1-16.3 |
|
65 years |
5.6-15.6 |
7.1-16.3 |
|
66 years |
5.7-15.6 |
7.1-16.3 |
|
67 years |
5.7-15.7 |
7.2-16.3 |
|
68 years |
5.8-15.7 |
7.2-16.3 |
|
69 years |
5.9-15.7 |
7.2-16.3 |
|
70 years |
6.0-15.8 |
7.3-16.3 |
|
71 years |
6.1-15.8 |
7.3-16.3 |
|
72 years |
6.2-15.8 |
7.3-16.3 |
|
73 years |
6.3-15.9 |
7.3-16.3 |
|
74 years |
6.4-15.9 |
7.3-16.3 |
|
75 years |
6.5-15.9 |
7.3-16.3 |
|
76 years |
6.6-15.9 |
7.3-16.3 |
|
77 years |
6.7-16.0 |
7.4-16.3 |
|
78 years |
6.8-16.0 |
7.4-16.3 |
|
79 years |
6.9-16.0 |
7.5-16.3 |
|
80 years |
7.0-16.0 |
7.5-16.3 |
|
81 years |
7.1-16.0 |
7.7-16.2 |
|
82 years |
7.2-16.0 |
7.8-16.2 |
|
83 years |
7.2-16.0 |
7.9-16.2 |
|
84 years |
7.3-16.0 |
8.0-16.2 |
|
85 years |
7.3-16.0 |
8.2-16.2 |
|
>85 years |
7.4-16.0 |
8.3-16.2 |
Day(s) Performed
Monday through FridayPerforming Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
83090
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| HCYSS | Homocysteine, Total, S | 13965-9 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 35836 | Homocysteine, Total, S | 13965-9 |
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.Disease States
- Homocystinuria
Report Available
3 to 5 daysNY State Approved
YesForms
1. Biochemical Genetics Patient Information (T602)
2. If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-Biochemical Genetics Test Request (T798)
-Cardiovascular Test Request (T724)