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Test ID FB12 Vitamin B12 and Folate, Serum

Useful For

Investigation of macrocytic anemia

 

Workup of deficiencies seen in megaloblastic anemias

 

Investigation of suspected folate deficiency

 

Diagnosis of vitamin B12 deficiency-associated neuropathy

Special Instructions

Method Name

B12: Immunoenzymatic Assay

FOL: Competitive Binding Receptor Assay

Reporting Name

Vitamin B12 and Folate, S

Specimen Type

Serum


Specimen Required


Patient Preparation:

1. Fasting: 8 hours, required

2. Do not order on patients who have recently received methotrexate or other folic acid antagonists.

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL serum

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

Serum: 0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 7 days
  Frozen  90 days

Reference Values

VITAMIN B12

180-914 ng/L

 

FOLATE

≥4.0 mcg/L

<4.0 mcg/L suggests folate deficiency

Day(s) Performed

Monday through Friday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

82607-Vitamin B12

82746-Folate

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FB12 Vitamin B12 and Folate, S 96805-7

 

Result ID Test Result Name Result LOINC Value
B12 Vitamin B12 Assay, S 2132-9
FOL Folate, S 2284-8

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

Profile Information

Test ID Reporting Name Available Separately Always Performed
B12 Vitamin B12 Assay, S Yes Yes
FOL Folate, S Yes Yes

Testing Algorithm

For more information, see Vitamin B12 Deficiency Evaluation.

Disease States

  • Homocystinuria

Report Available

1 to 3 days

NY State Approved

Yes

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Kidney Transplant Test Request

-Benign Hematology Test Request Form (T755)