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HelpTest ID DIS Human Leukocyte Antigens (HLA) Class I and II Disease Association Typing, Low Resolution, Blood
Ordering Guidance
This test should be ordered if both human leukocyte antigen (HLA) Class I and Class II results are wanted for disease association.
If only needing patient's HLA Class I typing for disease association, order 1DIS / Human Leukocyte Antigens (HLA)-A-B-C Disease Association Typing Low Resolution, Blood.
If only needing patient's HLA Class II typing for disease association, order 2DIS / Human Leukocyte Antigens (HLA)-DR-DQ Disease Association Typing Low Resolution, Blood.
Specimen Required
Container/Tube: Yellow top (ACD solution A or B)
Specimen Volume: 6 mL
Collection Instructions: Send whole blood in original tube. Do not aliquot.
Additional Information: Specimen acceptability is based on extracted DNA concentration and not sample age.
Useful For
Identifying class I and II human leukocyte antigens (HLA) for potential disease associations or markers for drug hypersensitivity
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| 1DIS | HLA-A-B-C DisAssoc Typing LowRes,B | Yes | Yes |
| 2DIS | HLA-DR-DQ DisAssoc Typing LowRes,B | Yes | Yes |
Method Name
Polymerase Chain Reaction (PCR)/Next-Generation Sequencing (NGS)
Reporting Name
HLA CI-CII DisAssoc Typing LowRes,BSpecimen Type
Whole Blood ACDSpecimen Minimum Volume
3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole Blood ACD | Ambient (preferred) | ||
| Refrigerated | |||
Reference Values
Not applicable
Day(s) Performed
Monday, Thursday
Report Available
7 to 17 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
81370
81376 x3
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| DIS | HLA CI-CII DisAssoc Typing LowRes,B | 98005-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 1DA02 | ABC DisAssoc Comment | 96625-9 |
| 2DA02 | DRDQ DisAssoc Comment | 96625-9 |
| 2DA03 | DRB1 - 1 Equivalent | 57298-2 |
| 1DA03 | A - 1 Equivalent | 13298-5 |
| 1DA04 | A - 2 Equivalent | 13298-5 |
| 2DA04 | DRB1 - 2 Equivalent | 57298-2 |
| 2DA05 | DRB1 - 1 Molecular | 96664-8 |
| 1DA05 | A - 1 Molecular | 78014-8 |
| 1DA06 | A - 2 Molecular | 78014-8 |
| 2DA06 | DRB1 - 2 Molecular | 96664-8 |
| 2DA07 | DRB345 - 1 Equivalent | 96673-9 |
| 1DA07 | B - 1 Equivalent | 13299-3 |
| 1DA08 | B - 2 Equivalent | 13299-3 |
| 2DA08 | DRB345 - 2 Equivalent | 96673-9 |
| 2DA09 | DRB345 - 1 Molecular | 96672-1 |
| 1DA09 | B - 1 Molecular | 78015-5 |
| 1DA10 | B - 2 Molecular | 78015-5 |
| 2DA10 | DRB345 - 2 Molecular | 96672-1 |
| 2DA11 | DQB1 - 1 Equivalent | 53938-7 |
| 1DA11 | Bw - 1 Equivalent | 96633-3 |
| 1DA12 | Bw - 2 Equivalent | 96633-3 |
| 2DA12 | DQB1 - 2 Equivalent | 53938-7 |
| 2DA13 | DQB1 - 1 Molecular | 78017-1 |
| 1DA13 | C - 1 Equivalent | 13302-5 |
| 1DA14 | C - 2 Equivalent | 13302-5 |
| 2DA14 | DQB1 - 2 Molecular | 78017-1 |
| 2DA15 | DQA1 - 1 Molecular | 96654-9 |
| 1DA15 | C - 1 Molecular | 96636-6 |
| 1DA16 | C - 2 Molecular | 96636-6 |
| 2DA16 | DQA1 - 2 Molecular | 96654-9 |
| 2DA17 | DPB1 - 1 Molecular | 96648-1 |
| LRTM1 | Test Method | 85069-3 |
| 2DA18 | DPB1 - 2 Molecular | 96648-1 |
| 2DA19 | DPA1 - 1 Molecular | 96643-2 |
| 2DA20 | DPA1 - 2 Molecular | 96643-2 |
| LRTM2 | Test Method | 85069-3 |