Test ID CRCOF Chromium and Cobalt, Synovial Fluid
Ordering Guidance
This test should only be used in individuals with chromium or cobalt implants.
Specimen Required
Patient Preparation: High concentrations of gadolinium and iodine are known to interfere with most inductively coupled plasma mass spectrometry-based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for at least 96 hours.
Supplies: Metal Free B-D Tube (EDTA), 6 mL (T183)
Container/Tube: Royal blue top (metal-free EDTA)
Specimen Volume: 1 mL
Collection Instructions: See Metals Analysis Specimen Collection and Transport for complete instructions.
Additional Information: Cobalt and chromium are present in the black rubber plunger seals found in most disposable syringes. As a result, synovial fluid should not be collected in these devices as contamination may occur.
Useful For
Monitoring metallic prosthetic implant wear and local tissue destruction in failed hip arthroplasty constructs
This test is not useful for assessment of vitamin B12 activity.
Profile Information
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
CRSY | Chromium, Synovial Fl | Yes | Yes |
COSY | Cobalt, Synovial Fl | Yes | Yes |
Special Instructions
Method Name
Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
Reporting Name
Chromium and Cobalt, Synovial FlSpecimen Type
Synovial FluidSpecimen Minimum Volume
0.4 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Synovial Fluid | Refrigerated (preferred) | 90 days | |
Ambient | 90 days | ||
Frozen | 90 days |
Reference Values
CHROMIUM:
0-17 years: Not established
≥18 years: <16.9 ng/mL
COBALT:
0-17 years: Not established
≥18 years: <19.8 ng/mL
Day(s) Performed
Friday
Report Available
2 to 8 daysPerforming Laboratory
Mayo Clinic Laboratories in RochesterTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83018
82495
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
CRCOF | Chromium and Cobalt, Synovial Fl | 95525-2 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
606352 | Cobalt, Synovial Fl | 23842-8 |
606353 | Chromium, Synovial Fl | 95526-0 |