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HelpTest ID CMMPP Cobalamin, Methionine, and Methylmalonic Acid Pathways, Plasma
Necessary Information
Patient's age and sex are required.
Specimen Required
Collection Container/Tube:
Preferred: Lavender top (EDTA)
Acceptable: Green top (sodium or lithium heparin)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Immediately place specimen on ice.
2. Centrifuge and aliquot plasma into plastic vial within 4 hours of collection.
3. If blood cannot be placed on wet ice immediately, centrifuge and aliquot plasma into plastic vial within 1 hour of collection.
4. A refrigerated centrifuge is not required if the above time restrictions are met.
Forms
1. Biochemical Genetics Patient Information (T602)
2. If not ordering electronically, complete, print, and send a Biochemical Genetics Test Request (T798) with the specimen.
Useful For
Screening and monitoring patients suspected of or confirmed with an inherited disorder of methionine, cobalamin, or propionate metabolism using plasma specimens
Evaluating individuals with suspected deficiency of vitamin B12
Disease States
- Homocystinuria
Special Instructions
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
CMMP, PSpecimen Type
PlasmaSpecimen Minimum Volume
0.3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma | Refrigerated (preferred) | 28 days | |
| Frozen | 309 days | ||
| Ambient | 28 days |
Reference Values
|
Age |
Total homocysteine |
Methylmalonic acid (nmol/mL) |
2-Methylcitric |
Total cysteine |
Methionine (nmol/mL) |
Cystathionine |
|
|||
|
Female |
Male |
Female |
Male |
|||||||
|
0-11 months |
3.1-8.3 |
3.2-9.7 |
0.08-0.32 |
0.02-0.35 |
142.8-258.8 |
14.7-43.1 |
14.5-42.3 |
0.07-0.38 |
||
|
12-23 months |
3.2-8.3 |
3.3-9.6 |
0.08-0.31 |
0.02-0.35 |
143.7-258.7 |
14.7-43.1 |
14.5-42.2 |
0.07-0.38 |
||
|
24-35 months |
3.2-8.2 |
3.3-9.6 |
0.08-0.31 |
0.02-0.35 |
144.8-258.6 |
14.7-43.0 |
14.5-42.1 |
0.07-0.38 |
||
|
3 years |
3.2-8.2 |
3.3-9.6 |
0.08-0.31 |
0.02-0.35 |
146.0-258.5 |
14.7-43.0 |
14.5-42.0 |
0.07-0.38 |
||
|
4 years |
3.3-8.2 |
3.4-9.5 |
0.08-0.30 |
0.02-0.35 |
148.2-258.4 |
14.7-42.8 |
14.5-41.8 |
0.07-0.38 |
||
|
5 years |
3.4-8.1 |
3.5-9.4 |
0.08-0.30 |
0.02-0.35 |
150.6-258.3 |
14.8-42.7 |
14.5-41.6 |
0.07-0.38 |
||
|
6 years |
3.5-8.1 |
3.6-9.4 |
0.08-0.29 |
0.02-0.35 |
153.2-258.3 |
14.8-42.5 |
14.5-41.4 |
0.07-0.38 |
||
|
7 years |
3.5-8.1 |
3.7-9.4 |
0.08-0.29 |
0.02-0.35 |
155.8-258.4 |
14.8-42.2 |
14.5-41.1 |
0.07-0.38 |
||
|
8 years |
3.6-8.2 |
3.8-9.3 |
0.08-0.28 |
0.02-0.35 |
158.5-258.7 |
14.9-42.0 |
14.6-40.9 |
0.07-0.37 |
||
|
9 years |
3.7-8.2 |
3.9-9.4 |
0.09-0.28 |
0.02-0.35 |
161.0-259.1 |
14.9-41.7 |
14.6-40.7 |
0.07-0.37 |
||
|
10 years |
3.8-8.3 |
4.1-9.4 |
0.09-0.28 |
0.02-0.35 |
163.5-259.7 |
15.0-41.4 |
14.7-40.6 |
0.07-0.37 |
||
|
11 years |
3.9-8.4 |
4.3-9.4 |
0.09-0.28 |
0.02-0.35 |
165.9-260.5 |
15.1-41.0 |
14.8-40.4 |
0.07-0.37 |
||
|
12 years |
3.9-8.6 |
4.4-9.5 |
0.09-0.27 |
0.02-0.35 |
168.4-261.4 |
15.1-40.7 |
14.9-40.3 |
0.07-0.37 |
||
|
13 years |
4.0-8.7 |
4.6-9.6 |
0.09-0.27 |
0.02-0.35 |
170.9-262.4 |
15.2-40.3 |
15.1-40.1 |
0.07-0.36 |
||
|
14 years |
4.1-8.8 |
4.8-9.7 |
0.09-0.27 |
0.02-0.35 |
173.6-263.6 |
15.3-39.9 |
15.3-40.0 |
0.07-0.36 |
||
|
15 years |
4.2-8.9 |
5.0-9.8 |
0.09-0.27 |
0.02-0.35 |
176.4-264.7 |
15.4-39.5 |
15.5-39.9 |
0.07-0.36 |
||
|
16 years |
4.2-9.1 |
5.2-9.9 |
0.09-0.27 |
0.02-0.35 |
179.3-265.9 |
15.5-39.1 |
15.8-39.7 |
0.07-0.35 |
||
|
17 years |
4.3-9.2 |
5.4-10.0 |
0.09-0.27 |
0.02-0.35 |
182.2-267.1 |
15.6-38.7 |
16.1-39.6 |
0.07-0.35 |
||
|
18 years |
4.3-9.3 |
5.6-10.1 |
0.08-0.27 |
0.02-0.35 |
184.9-268.3 |
15.7-38.2 |
16.4-39.4 |
0.07-0.35 |
||
|
19 years |
4.4-9.5 |
5.7-10.3 |
0.08-0.26 |
0.02-0.35 |
187.4-269.4 |
15.7-37.8 |
16.7-39.3 |
0.07-0.34 |
||
|
20 years |
4.4-9.6 |
5.9-10.5 |
0.08-0.26 |
0.02-0.35 |
189.5-270.5 |
15.8-37.3 |
17.0-39.1 |
0.07-0.34 |
||
|
21 years |
4.4-9.8 |
6.0-10.6 |
0.08-0.26 |
0.02-0.35 |
191.2-271.7 |
15.9-36.8 |
17.3-38.9 |
0.07-0.33 |
||
|
22 years |
4.4-9.9 |
6.1-10.8 |
0.08-0.27 |
0.02-0.35 |
192.5-272.8 |
15.9-36.3 |
17.6-38.7 |
0.07-0.33 |
||
|
23 years |
4.4-10.1 |
6.2-11.0 |
0.08-0.27 |
0.02-0.35 |
193.5-274.1 |
15.9-35.8 |
17.9-38.5 |
0.07-0.33 |
||
|
24 years |
4.4-10.3 |
6.2-11.1 |
0.08-0.27 |
0.02-0.35 |
194.2-275.4 |
15.9-35.3 |
18.1-38.3 |
0.07-0.32 |
||
|
25 years |
4.4-10.4 |
6.3-11.3 |
0.08-0.28 |
0.02-0.35 |
194.8-277.0 |
15.9-34.8 |
18.2-38.1 |
0.07-0.32 |
||
|
26 years |
4.4-10.6 |
6.3-11.4 |
0.08-0.28 |
0.02-0.35 |
195.3-278.6 |
15.9-34.3 |
18.4-37.9 |
0.07-0.32 |
||
|
27 years |
4.3-10.8 |
6.4-11.6 |
0.08-0.28 |
0.02-0.35 |
196.0-280.5 |
16.0-33.8 |
18.5-37.7 |
0.07-0.31 |
||
|
28 years |
4.3-11.0 |
6.4-11.7 |
0.08-0.29 |
0.02-0.35 |
196.7-282.4 |
16.0-33.4 |
18.7-37.5 |
0.07-0.31 |
||
|
29 years |
4.3-11.2 |
6.4-11.8 |
0.08-0.29 |
0.02-0.35 |
197.7-284.3 |
16.0-33.0 |
18.8-37.3 |
0.07-0.31 |
||
|
30 years |
4.3-11.4 |
6.4-11.9 |
0.08-0.30 |
0.02-0.35 |
198.8-286.3 |
16.1- 32.6 |
18.9-37.1 |
0.07-0.30 |
||
|
31 years |
4.4-11.6 |
6.4-12.1 |
0.08-0.30 |
0.02-0.35 |
200.2-288.2 |
16.1-32.2 |
19.0-36.9 |
0.07-0.30 |
||
|
32 years |
4.4-11.8 |
6.4-12.2 |
0.08-0.31 |
0.02-0.35 |
201.7-290.0 |
16.1-31.8 |
19.1-36.7 |
0.07-0.30 |
||
|
33 years |
4.4-11.9 |
6.4-12.3 |
0.08-0.31 |
0.02-0.35 |
203.4-291.5 |
16.1-31.5 |
19.2-36.5 |
0.07-0.29 |
||
|
34 years |
4.5-12.1 |
6.4-12.4 |
0.08-0.31 |
0.02-0.35 |
205.2-292.9 |
16.1-31.2 |
19.3-36.3 |
0.07-0.29 |
||
|
35 years |
4.5-12.2 |
6.4-12.6 |
0.08-0.32 |
0.02-0.35 |
207.2-294.1 |
16.1-30.8 |
19.4-36.1 |
0.07-0.28 |
||
|
36 years |
4.6-12.4 |
6.4-12.8 |
0.08-0.32 |
0.02-0.35 |
209.3-295.1 |
16.1-30.5 |
19.5-35.9 |
0.07-0.28 |
||
|
37 years |
4.6-12.5 |
6.4-12.9 |
0.08-0.33 |
0.02-0.35 |
211.5-296.0 |
16.1-30.2 |
19.6-35.6 |
0.07-0.27 |
||
|
38 years |
4.7-12.7 |
6.4-13.1 |
0.08-0.33 |
0.02-0.35 |
213.8-296.9 |
16.1-29.9 |
19.7-35.4 |
0.07-0.27 |
||
|
39 years |
4.7-12.8 |
6.4-13.2 |
0.08-0.34 |
0.02-0.35 |
216.3-297.7 |
16.1-29.7 |
19.8-35.2 |
0.07-0.27 |
||
|
40 years |
4.8-13.0 |
6.5-13.4 |
0.08-0.34 |
0.02-0.35 |
218.9-298.7 |
16.1-29.4 |
19.9-35.0 |
0.07-0.27 |
||
|
41 years |
4.8-13.2 |
6.5-13.5 |
0.08-0.35 |
0.02-0.35 |
221.6-299.7 |
16.1-29.2 |
20.0-34.8 |
0.07-0.27 |
||
|
42 years |
4.8-13.4 |
6.5-13.7 |
0.08-0.36 |
0.02-0.35 |
224.3-300.8 |
16.2-29.0 |
20.1-34.6 |
0.07-0.26 |
||
|
43 years |
4.9-13.5 |
6.6-13.9 |
0.08-0.36 |
0.02-0.35 |
227.0-302.0 |
16.2-28.8 |
20.2-34.4 |
0.07-0.26 |
||
|
44 years |
4.9-13.7 |
6.6-14.0 |
0.08-0.37 |
0.02-0.35 |
229.8-303.5 |
16.3-28.6 |
20.3-34.2 |
0.07-0.26 |
||
|
45 years |
4.9-13.9 |
6.6-14.2 |
0.08-0.38 |
0.02-0.35 |
232.6-305.2 |
16.3-28.5 |
20.3-34.0 |
0.07-0.26 |
||
|
46 years |
4.9-14.0 |
6.7-14.4 |
0.08-0.38 |
0.02-0.35 |
235.3-307.3 |
16.4-28.4 |
20.4-33.8 |
0.07-0.26 |
||
|
47 years |
4.9-14.2 |
6.7-14.5 |
0.08-0.39 |
0.02-0.35 |
238.0-309.7 |
16.4-28.2 |
20.4-33.6 |
0.07-0.26 |
||
|
48 years |
5.0-14.3 |
6.8-14.7 |
0.08-0.39 |
0.02-0.35 |
240.8-312.6 |
16.5-28.1 |
20.5-33.3 |
0.07-0.26 |
||
|
49 years |
5.0-14.4 |
6.8-14.9 |
0.08-0.40 |
0.02-0.35 |
243.5-315.9 |
16.5-28.0 |
20.5-33.1 |
0.07-0.26 |
||
|
50 years |
5.0-14.5 |
6.8-15.0 |
0.08-0.40 |
0.02-0.35 |
246.2-319.7 |
16.5-27.9 |
20.6-32.8 |
0.07-0.26 |
||
|
51 years |
5.1-14.6 |
6.8-15.2 |
0.08-0.41 |
0.02-0.35 |
248.9-323.8 |
16.5-27.8 |
20.6-32.5 |
0.07-0.26 |
||
|
52 years |
5.1-14.7 |
6.9-15.4 |
0.08-0.41 |
0.02-0.35 |
251.5-328.1 |
16.5-27.6 |
20.7-32.3 |
0.07-0.26 |
||
|
53 years |
5.1-14.8 |
6.9-15.5 |
0.08-0.42 |
0.02-0.35 |
254.0-332.4 |
16.5-27.5 |
20.8-32.1 |
0.07-0.26 |
||
|
54 years |
5.2-14.9 |
6.9-15.6 |
0.08-0.42 |
0.02-0.35 |
256.4-336.5 |
16.5-27.4 |
21.0-31.9 |
0.07-0.25 |
||
|
55 years |
5.2-15.0 |
6.9-15.7 |
0.08-0.43 |
0.02-0.35 |
258.6-340.2 |
16.5-27.3 |
21.1-31.7 |
0.07-0.25 |
||
|
56 years |
5.3-15.0 |
6.9-15.8 |
0.08-0.43 |
0.02-0.35 |
260.6-343.6 |
16.6-27.2 |
21.2-31.5 |
0.07-0.25 |
||
|
57 years |
5.3-15.1 |
6.9-15.9 |
0.08-0.44 |
0.02-0.35 |
262.5-346.5 |
16.6-27.1 |
21.2-31.3 |
0.07-0.25 |
||
|
58 years |
5.3-15.2 |
6.9-16.0 |
0.08-0.44 |
0.02-0.35 |
264.3-349.0 |
16.6-27.1 |
21.3-31.0 |
0.07-0.25 |
||
|
59 years |
5.4-15.2 |
6.9-16.0 |
0.08-0.44 |
0.02-0.35 |
266.2-351.1 |
16.7-27.1 |
21.3-30.8 |
0.07-0.25 |
||
|
60 years |
5.4-15.3 |
6.9-16.1 |
0.08-0.45 |
0.02-0.35 |
268.3-353.1 |
16.8-27.1 |
21.3-30.6 |
0.07-0.25 |
||
|
61 years |
5.4-15.4 |
7.0-16.2 |
0.09-0.45 |
0.02-0.35 |
270.8-355.1 |
16.9-27.2 |
21.3-30.3 |
0.07-0.25 |
||
|
62 years |
5.5-15.4 |
7.0-16.2 |
0.09-0.46 |
0.02-0.35 |
273.8-357.3 |
17.0-27.2 |
21.2-30.0 |
0.08-0.25 |
||
|
63 years |
5.5-15.5 |
7.0-16.3 |
0.09-0.46 |
0.02-0.35 |
277.5-359.7 |
17.1-27.3 |
21.2-29.8 |
0.08-0.25 |
||
|
64 years |
5.6-15.5 |
7.1-16.3 |
0.09-0.46 |
0.02-0.35 |
281.9-362.3 |
17.2-27.4 |
21.1-29.5 |
0.08-0.25 |
||
|
65 years |
5.6-15.6 |
7.1-16.3 |
0.09-0.47 |
0.02-0.35 |
286.9-365.2 |
17.3-27.6 |
21.1-29.2 |
0.08-0.25 |
||
|
66 years |
5.7-15.6 |
7.1-16.3 |
0.09-0.47 |
0.02-0.35 |
292.4-368.3 |
17.4-27.7 |
21.1-29.0 |
0.08-0.25 |
||
|
67 years |
5.7-15.7 |
7.2-16.3 |
0.09-0.47 |
0.02-0.35 |
298.1-371.6 |
17.5-27.8 |
21.0-28.7 |
0.09-0.25 |
||
|
68 years |
5.8-15.7 |
7.2-16.3 |
0.09-0.47 |
0.02-0.35 |
303.6-374.8 |
17.7-27.9 |
21.0-28.5 |
0.09-0.25 |
||
|
69 years |
5.9-15.7 |
7.2-16.3 |
0.09-0.47 |
0.02-0.35 |
308.7-377.8 |
17.8-28.0 |
21.0-28.4 |
0.09-0.25 |
||
|
70 years |
6.0-15.8 |
7.3-16.3 |
0.09-0.48 |
0.02-0.35 |
313.1-380.7 |
18.0-28.1 |
21.0-28.3 |
0.09-0.25 |
||
|
71 years |
6.1-15.8 |
7.3-16.3 |
0.09-0.48 |
0.02-0.35 |
316.5-383.2 |
18.1-28.2 |
20.9-28.2 |
0.09-0.25 |
||
|
72 years |
6.2-15.8 |
7.3-16.3 |
0.09-0.48 |
0.02-0.35 |
318.9-385.3 |
18.3-28.3 |
20.9-28.0 |
0.09-0.25 |
||
|
73 years |
6.3-15.9 |
7.3-16.3 |
0.09-0.48 |
0.02-0.35 |
320.1-387.0 |
18.5-28.4 |
20.8-27.9 |
0.10-0.26 |
||
|
74 years |
6.4-15.9 |
7.3-16.3 |
0.09-0.48 |
0.02-0.35 |
320.6-388.3 |
18.8-28.5 |
20.8-27.8 |
0.10-0.26 |
||
|
75 years |
6.5-15.9 |
7.3-16.3 |
0.09-0.48 |
0.02-0.35 |
320.3-389.3 |
19.1-28.5 |
20.8-27.7 |
0.10-0.26 |
||
|
76 years |
6.6-15.9 |
7.3-16.3 |
0.09-0.48 |
0.02-0.35 |
319.6-389.9 |
19.3-28.6 |
20.8-27.5 |
0.10-0.26 |
||
|
77 years |
6.7-16.0 |
7.4-16.3 |
0.10-0.48 |
0.02-0.35 |
319.1-390.2 |
19.6-28.6 |
20.9-27.4 |
0.10-0.26 |
||
|
78 years |
6.8-16.0 |
7.4-16.3 |
0.10-0.48 |
0.02-0.35 |
318.5-390.5 |
20.0-28.7 |
20.9-27.2 |
0.11-0.26 |
||
|
79 years |
6.9-16.0 |
7.5-16.3 |
0.10-0.48 |
0.02-0.35 |
317.9-390.6 |
20.3-28.7 |
21.0-27.1 |
0.11-0.26 |
||
|
80 years |
7.0-16.0 |
7.5-16.3 |
0.10-0.48 |
0.02-0.35 |
317.9-390.6 |
20.3-28.7 |
21.0-27.1 |
0.11-0.26 |
||
|
81 years |
7.1-16.0 |
7.7-16.2 |
0.10-0.48 |
0.02-0.35 |
317.9-390.6 |
20.3-28.7 |
21.0-27.1 |
0.11-0.26 |
||
|
82 years |
7.2-16.0 |
7.8-16.2 |
0.10-0.48 |
0.02-0.35 |
317.9-390.6 |
20.3-28.7 |
21.0-27.1 |
0.11-0.26 |
||
|
83 years |
7.2-16.0 |
7.9-16.2 |
0.10-0.48 |
0.02-0.35 |
317.9-390.6 |
20.3-28.7 |
21.0-27.1 |
0.11-0.26 |
||
|
84 years |
7.3-16.0 |
8.0-16.2 |
0.10-0.48 |
0.02-0.35 |
317.9-390.6 |
20.3-28.7 |
21.0-27.1 |
0.11-0.26 |
||
|
85 years |
7.3-16.0 |
8.2-16.2 |
0.10-0.48 |
0.02-0.35 |
317.9-390.6 |
20.3-28.7 |
21.0-27.1 |
0.11-0.26 |
||
|
>85 years |
7.4-16.0 |
8.3-16.2 |
0.10-0.48 |
0.02-0.35 |
317.9-390.6 |
20.3-28.7 |
21.0-27.1 |
0.11-0.26 |
||
Day(s) Performed
Monday through FridayReport Available
3 to 5 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83090
83918
82136
82542 (if appropriate for government payers)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CMMPP | CMMP, P | 104535-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 606110 | Interpretation | 59462-2 |
| 606104 | Total Homocysteine | 13965-9 |
| 606105 | Methylmalonic acid | 13964-2 |
| 606119 | 2-Methylcitric acid | 26904-3 |
| 606106 | Methionine | 20651-6 |
| 606107 | Total Cysteine | 20641-7 |
| 606108 | Cystathionine | 26607-2 |
| 606109 | Reviewed By | 18771-6 |