Test ID CARBR Carbamazepine Hypersensitivity Pharmacogenomics, Varies
Specimen Required
Multiple genotype tests can be performed on a single specimen after a single extraction. See Multiple Genotype Test List for a list of tests that can be ordered together.
Submit only 1 of the following specimens:
Specimen Type: Whole blood
Container/Tube: Lavender top (EDTA)
Specimen Volume: 3 mL
Collection Instructions:
1. Invert several times to mix blood.
2. Send whole blood specimen in original tube. Do not aliquot.
Specimen Stability Information: Ambient (preferred) 9 days/Refrigerated 30 days
Specimen Type: Saliva
Supplies: Saliva Swab Collection Kit (T786)
Patient Preparation: Patient should not eat, drink, smoke, or chew gum 30 minutes prior to collection.
Specimen Volume: 1 Swab
Collection Instructions: Collect and send specimen per kit instructions.
Specimen Stability Information: Ambient 30 days
Specimen Type: Extracted DNA
Container/Tube: 2-mL screw top tube
Specimen Volume: 100 mcL (microliters)
Collection Instructions:
1. The preferred volume is 100 mcL at a concentration of 50 ng/mcL.
2. Provide concentration of DNA and volume on tube.
Specimen Stability Information: Frozen (preferred) 1 year/Ambient/Refrigerated
Forms
1. New York Clients-Informed consent is required. Document on the request form or electronic order that a copy is on file. The following documents are available:
-Informed Consent for Genetic Testing (T576)
-Informed Consent for Genetic Testing-Spanish (T826)
2. If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-Therapeutics Test Request (T831)
Useful For
Identifying individuals with increased risk of risk of carbamazepine- or oxcarbazepine-associated cutaneous adverse reactions
Genetics Test Information
Detection of the HLA-B*15:02 allele (HLA00165) in the HLA-B gene (NM_005514).
Detection of the HLA-A*31:01 allele (HLA00097) in the HLA-A gene (NM_001242758).
Special Instructions
Method Name
Qualitative Allele-Specific Real-Time Polymerase Chain Reaction (PCR)
Reporting Name
Carbamazepine PGx Panel, VSpecimen Type
VariesSpecimen Minimum Volume
Blood: 0.35 mL
Saliva, extracted DNA: see Specimen Required
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Varies | Varies |
Reference Values
An interpretive report will be provided.
Day(s) Performed
Monday, Wednesday through Friday
Report Available
1 to 5 daysPerforming Laboratory
Mayo Clinic Laboratories in RochesterTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
81381 x 2
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
CARBR | Carbamazepine PGx Panel, V | 94855-4 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
610657 | HLA-A*31:01 Genotype | 79712-6 |
610658 | HLA-B*15:02 Genotype | 57979-7 |
610659 | Carbamazepine PGx Panel Phenotype | 93308-5 |
610660 | Interpretation | 69047-9 |
610661 | Additional Information | 48767-8 |
610662 | Method | 85069-3 |
610663 | Disclaimer | 62364-5 |
610664 | Reviewed by | 18771-6 |